Fresh frozen plasma
The use of fresh frozen plasma is the only immune reinforcement for new born puppies. Puppies that ingest plasma during the first 36 hours of life have a higher weight gain and more energy than those that don not.
The digestive system of newborns is not fully functional during this first 36 hours and therefore permeable to the immunoglobulins administered. That is why it is so important that the take calostrum during the first hours of life. After this time the intestinal barrier does not permit the absorption of the immunoglobulins administered orally and have to be administered in other ways.
The Cryocel Kit for immune reinforcement contains individual 12 ml plastic containers of frozen plasma, this make it easier to preserve.
In the inside you will find instructions for use. REQUEST
1.- Keep it frozen until use.
2.- Defreeze if possible only the amount to be used. Put it in warm water (never hot) until it reaches body temperature (36-37 ºC). Keep the rest in refrigeration until use.
3.- Calculate the dose to administer per puppy. You need to weigh the puppy and administer a total dose of 3-5ml per lb. This total dose is to be administered every 3-3 hours and throughout the first 24-36 hours of life orally.
4.- Use all the defrozen plasma before 24 hours.
5.- After 36 hours the plasma can Only be given intravenously or intraperitoneally. Orally does not work any more.
6.- Puppies are normally treated only once. It can be repeated after 5 or 7 days in case of deaths in the litter.
Frozen plasma can be administered at any time during the first 10 days of life if any of the weak puppy syndrome symptoms are found. The administration must be done by a veterinarian, because only the intravenous or intraperitoneal routes are effective.
The dose for small puppies is 3 to 4 ml, and 4.5 ml per lb for larger breeds. Do not administer more than 10 ml at once.
Bouchard, M et al 1992 & quot;Absorption of Immunoglobulins in puppies; AM J Vet Res. 53:230-233.
Dodds, W. J. 1993;Known medical indications for the use of fresh frozen plasma;" DVM Magazine 24 (4): 42-43
Poffenberger, E.M. & Olson P.N., et al 1991; Use of adult dog serum as a substitute for calostrum in the newborn.AM J Vet Res. 52: 1221_1224.